3EXE

Crystal structure of the pyruvate dehydrogenase (E1p) component of human pyruvate dehydrogenase complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, C, E, G)	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	polymer	382	42584.5	4	UniProt (P08559) Pfam (PF00676)	Homo sapiens (human)	pyruvate dehydrogenase (E1p) alpha subunit; PDHE1-A type I
2	B, D, F, H (B, D, F, H)	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	polymer	329	35941.3	4	UniProt (P11177) Pfam (PF02779) Pfam (PF02780)	Homo sapiens (human)	pyruvate dehydrogenase (E1p) beta subunit; PDHE1-B
3	I, M, Q, U (A, C, E, G)	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)
4	J, N, R, V (A, C, E, G)	THIAMINE DIPHOSPHATE	non-polymer		425.3	4	Chemie (TPP)
5	K, O, S, W (A, C, E, G)	GLYCEROL	non-polymer		92.1	4	Chemie (GOL)
6	L, P, T, X (B, D, F, H)	POTASSIUM ION	non-polymer		39.1	4	Chemie (K)
7	AA, BA, CA, DA, EA... (C, D, E, F, G...)	water	water		18.0	2316	Chemie (HOH)

Sequence modifications

A, C, E, G: 1 - 361 (UniProt: P08559)

PDB	External Database	Details
Met -20	-	expression tag
Gly -19	-	expression tag
Ser -18	-	expression tag
Ser -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
Gly -8	-	expression tag
Leu -7	-	expression tag
Val -6	-	expression tag
Pro -5	-	expression tag
Arg -4	-	expression tag
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag
Met 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	314103.3
Non-Polymers*	Number of molecules	16
	Total formula weight	2445.8
All*	Total formula weight	316549.1

*Water molecules are not included.