3EQL

Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic myxopyronin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, K, L	DNA-directed RNA polymerase subunit alpha	polymer	315	35056.2	4	UniProt (Q9Z9H6) Pfam (PF01193) Pfam (PF01000) Pfam (PF03118) In PDB	Thermus thermophilus	RNAP subunit alpha, Transcriptase subunit alpha, RNA polymerase subunit alpha
2	C, M	DNA-directed RNA polymerase subunit beta	polymer	1119	125436.5	2	UniProt (Q8RQE9) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF10385) Pfam (PF00562) Pfam (PF04560) In PDB	Thermus thermophilus	RNAP subunit beta, Transcriptase subunit beta, RNA polymerase subunit beta
3	D, N	DNA-directed RNA polymerase subunit beta'	polymer	1524	170997.4	2	UniProt (Q8RQE8) Pfam (PF04997) Pfam (PF21668) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) In PDB	Thermus thermophilus	RNAP subunit beta', Transcriptase subunit beta', RNA polymerase subunit beta'
4	E, O	DNA-directed RNA polymerase subunit omega	polymer	99	11533.3	2	UniProt (Q8RQE7) Pfam (PF01192) In PDB	Thermus thermophilus	RNAP omega subunit, Transcriptase subunit omega, RNA polymerase omega subunit
5	F, P	RNA polymerase sigma factor rpoD	polymer	423	48568.0	2	UniProt (Q72L95) Pfam (PF00140) Pfam (PF04542) Pfam (PF04539) Pfam (PF04545) UniProt (by SIFTS) (Q5SKW1) In PDB	Thermus thermophilus
6	D, N	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
7	D, N	Myxopyronin B	non-polymer		417.5	2	Chemie (MXP)
8	D, N	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
9		water	water		18.0	4496	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	12
	Total formula weight	853295.2
Non-Polymers*	Number of molecules	8
	Total formula weight	1145.2
All*	Total formula weight	854440.4

*Water molecules are not included.