3EQL
Crystal structure of the T. Thermophilus RNA polymerase holoenzyme in complex with antibiotic myxopyronin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, G, H (A, B, K, L) | DNA-directed RNA polymerase subunit alpha | polymer | 315 | 35056.2 | 4 | UniProt (Q9Z9H6) Pfam (PF01193) Pfam (PF01000) Pfam (PF03118) | Thermus thermophilus | RNAP subunit alpha, Transcriptase subunit alpha, RNA polymerase subunit alpha |
| 2 | C, I (C, M) | DNA-directed RNA polymerase subunit beta | polymer | 1119 | 125436.5 | 2 | UniProt (Q8RQE9) Pfam (PF04563) Pfam (PF04561) Pfam (PF04565) Pfam (PF10385) Pfam (PF00562) Pfam (PF04560) | Thermus thermophilus | RNAP subunit beta, Transcriptase subunit beta, RNA polymerase subunit beta |
| 3 | D, J (D, N) | DNA-directed RNA polymerase subunit beta' | polymer | 1524 | 170997.4 | 2 | UniProt (Q8RQE8) Pfam (PF04997) Pfam (PF21668) Pfam (PF00623) Pfam (PF04983) Pfam (PF05000) Pfam (PF04998) | Thermus thermophilus | RNAP subunit beta', Transcriptase subunit beta', RNA polymerase subunit beta' |
| 4 | E, K (E, O) | DNA-directed RNA polymerase subunit omega | polymer | 99 | 11533.3 | 2 | UniProt (Q8RQE7) Pfam (PF01192) | Thermus thermophilus | RNAP omega subunit, Transcriptase subunit omega, RNA polymerase omega subunit |
| 5 | F, L (F, P) | RNA polymerase sigma factor rpoD | polymer | 423 | 48568.0 | 2 | UniProt (Q72L95) Pfam (PF00140) Pfam (PF04542) Pfam (PF04539) Pfam (PF04545) UniProt (by SIFTS) (Q5SKW1) | Thermus thermophilus | |
| 6 | M, N, Q, R (D, N) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 7 | O, S (D, N) | Myxopyronin B | non-polymer | 417.5 | 2 | Chemie (MXP) | |||
| 8 | P, T (D, N) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 9 | AA, BA, CA, DA, EA... (K, L, M, N, O...) | water | water | 18.0 | 4496 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 853295.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1145.2 | |
| All* | Total formula weight | 854440.4 |
