3EPZ

Structure of the replication foci-targeting sequence of human DNA cytosine methyltransferase DNMT1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	DNA (cytosine-5)-methyltransferase 1	polymer	268	30415.2	2	UniProt (P26358) Pfam (PF12047)	Homo sapiens (Human)	Dnmt1, MCMT, DNA methyltransferase HsaI, DNA MTase HsaI, M.HsaI, CXXC-type zinc finger protein 9
2	C, G (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D (A)	beta-D-glucopyranose	non-polymer		180.2	1	Chemie (BGC)
4	E (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5	F (A)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
6	H, I (A, B)	water	water		18.0	91	Chemie (HOH)

Sequence modifications

A, B: 351 - 600 (UniProt: P26358)

PDB	External Database	Details
Mse 333	-	expression tag
His 334	-	expression tag
His 335	-	expression tag
His 336	-	expression tag
His 337	-	expression tag
His 338	-	expression tag
His 339	-	expression tag
Ser 340	-	expression tag
Ser 341	-	expression tag
Gly 342	-	expression tag
Arg 343	-	expression tag
Glu 344	-	expression tag
Asn 345	-	expression tag
Leu 346	-	expression tag
Tyr 347	-	expression tag
Phe 348	-	expression tag
Gln 349	-	expression tag
Gly 350	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	60830.4
Non-Polymers*	Number of molecules	5
	Total formula weight	426.1
All*	Total formula weight	61256.4

*Water molecules are not included.