3EML

The 2.6 A Crystal Structure of a Human A2A Adenosine Receptor bound to ZM241385.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Human Adenosine A2A receptor/T4 lysozyme chimera	polymer	488	54739.8	1	UniProt (P29274) UniProt (P00720) Pfam (PF00001) Pfam (PF00959) In PDB	Homo sapiens
2	A	4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol	non-polymer		337.3	1	Chemie (ZMA)
3	A	STEARIC ACID	non-polymer		284.5	5	Chemie (STE)
4	A	SULFATE ION	non-polymer		96.1	7	Chemie (SO4)
5		water	water		18.0	76	Chemie (HOH)

Sequence modifications

A: 2 - 208 (UniProt: P29274)

PDB	External Database	Details
Asp -14	-	expression tag
Tyr -13	-	expression tag
Lys -12	-	expression tag
Asp -11	-	expression tag
Asp -10	-	expression tag
Asp -9	-	expression tag
Asp -8	-	expression tag
Ala -7	-	expression tag
Met -6	-	expression tag
Gly -5	-	expression tag
Gln -4	-	expression tag
Pro -3	-	expression tag
Val -2	-	expression tag
Gly -1	-	expression tag
Ala 0	-	expression tag
Pro 1	-	expression tag
His 317	-	expression tag
His 318	-	expression tag
His 319	-	expression tag
His 320	-	expression tag
His 321	-	expression tag
His 322	-	expression tag
His 323	-	expression tag
His 324	-	expression tag
His 325	-	expression tag
His 326	-	expression tag

A: 1002 - 1161 (UniProt: P00720)
A: 222 - 316 (UniProt: P29274)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	54739.8
Non-Polymers*	Number of molecules	13
	Total formula weight	2432.2
All*	Total formula weight	57171.9

*Water molecules are not included.