3ELA
Crystal structure of active site inhibited coagulation factor VIIA mutant in complex with soluble tissue factor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Coagulation factor VIIA light chain | polymer | 152 | 17047.0 | 1 | UniProt (P08709) Pfam (PF00594) Pfam (PF00008) Pfam (PF14670) | Homo sapiens (human) | |
| 2 | B (H) | Coagulation factor VIIA heavy chain | polymer | 254 | 28086.2 | 1 | UniProt (P08709) Pfam (PF00089) | Homo sapiens (human) | |
| 3 | C (T) | Tissue factor | polymer | 209 | 23632.2 | 1 | UniProt (P13726) Pfam (PF01108) Pfam (PF09294) | Homo sapiens (human) | TF, Coagulation factor III, Thromboplastin |
| 4 | D (L) | alpha-D-glucopyranose | non-polymer | 180.2 | 1 | Chemie (GLC) | |||
| 5 | E (L) | alpha-L-fucopyranose | non-polymer | 164.2 | 1 | Chemie (FUC) | |||
| 6 | F (H) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 7 | G (H) | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-phenylalaninamide | non-polymer | 504.0 | 1 | BIRD (PRD_000369) Chemie (0Z6) | |||
| 8 | H, I, J (L, H, T) | water | water | 18.0 | 214 | Chemie (HOH) |
Sequence modifications
H: 153 - 406 (UniProt: P08709)
| PDB | External Database | Details |
|---|---|---|
| Asp 158 | Val 218 | engineered mutation |
| Val 296 | Glu 356 | engineered mutation |
| Gln 298 | Met 358 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 68765.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 888.4 | |
| All* | Total formula weight | 69653.8 |
