3EI2

Structure of hsDDB1-drDDB2 bound to a 16 bp abasic site containing DNA-duplex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	DNA damage-binding protein 1	polymer	1158	129253.9	1	UniProt (Q16531) Pfam (PF10433) Pfam (PF03178)	Homo sapiens (Human)	hsDDB1, Damage-specific DNA-binding protein 1, UV-damaged DNA-binding factor, DDB p127 subunit, DNA damage-binding protein a, DDBa, UV-damaged DNA-binding protein 1, UV-DDB 1, Xeroderma pigmentosum group E-complementing protein, XPCe, XPE-binding factor, XPE-BF, HBV X-associated protein 1, XAP-1
2	B (B)	DNA damage-binding protein 2	polymer	383	43559.1	1	UniProt (Q2YDS1) Pfam (PF00400)	Danio rerio (Zebrafish)	Damage-specific DNA-binding protein 2
3	C (G)	5'-D(*DAP*DAP*DAP*DTP*DGP*DAP*DAP*DTP*(3DR)P*DAP*DAP*DGP*DCP*DAP*DGP*DG)-3'	polymer	16	4855.2	1
4	D (H)	5'-D(*DCP*DCP*DTP*DGP*DCP*DTP*DTP*DTP*DAP*DTP*DTP*DCP*DAP*DTP*DTP*DT)-3'	polymer	16	4805.1	1
5	E (A)	TETRAETHYLENE GLYCOL	non-polymer		194.2	1	Chemie (PG4)
6	F, G, H, I (A, B, G, H)	water	water		18.0	282	Chemie (HOH)

Sequence modifications

A: 1 - 1140 (UniProt: Q16531)

PDB	External Database	Details
Met -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
Arg -10	-	expression tag
Arg -9	-	expression tag
Leu -8	-	expression tag
Val -7	-	expression tag
Pro -6	-	expression tag
Arg -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
Gly -2	-	expression tag
Gly -1	-	expression tag
Arg 0	-	expression tag

B: 94 - 457 (UniProt: Q2YDS1)

PDB	External Database	Details
Met 75	-	expression tag
His 76	-	expression tag
His 77	-	expression tag
His 78	-	expression tag
His 79	-	expression tag
His 80	-	expression tag
His 81	-	expression tag
Val 82	-	expression tag
Asp 83	-	expression tag
Glu 84	-	expression tag
Asn 85	-	expression tag
Leu 86	-	expression tag
Tyr 87	-	expression tag
Phe 88	-	expression tag
Gln 89	-	expression tag
Gly 90	-	expression tag
Gly 91	-	expression tag
Gly 92	-	expression tag
Arg 93	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	182473.3
Non-Polymers*	Number of molecules	1
	Total formula weight	194.2
All*	Total formula weight	182667.5

*Water molecules are not included.