3EE6

Crystal Structure Analysis of Tripeptidyl peptidase -I

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tripeptidyl-peptidase 1	polymer	571	62376.8	2	UniProt (O14773) Pfam (PF09286) Pfam (PF00082)	Homo sapiens (human)	TPP-1, Tripeptidyl-peptidase I, TPP-I, Tripeptidyl aminopeptidase, Lysosomal pepstatin-insensitive protease, LPIC, Cell growth-inhibiting gene 1 protein
2	C, D, E, F, N... (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG)
3	G, H, I, J, R... (A, B)	ZINC ION	non-polymer		65.4	8	Chemie (ZN)
4	K, V (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
5	L, W (A, B)	CALCIUM ION	non-polymer		40.1	2	Chemie (CA)
6	M, X (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
7	Y, Z (A, B)	water	water		18.0	73	Chemie (HOH)

Sequence modifications

A, B: 1 - 563 (UniProt: O14773)

PDB	External Database	Details
Arg 564	-	expression tag
Ser 565	-	expression tag
His 566	-	expression tag
His 567	-	expression tag
His 568	-	expression tag
His 569	-	expression tag
His 570	-	expression tag
His 571	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	124753.6
Non-Polymers*	Number of molecules	22
	Total formula weight	2636.1
All*	Total formula weight	127389.7

*Water molecules are not included.