3EDW
Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (X) | Thymidylate synthase | polymer | 313 | 35811.0 | 1 | UniProt (P04818) Pfam (PF00303) | Homo sapiens (Human) | TSase, TS |
| 2 | B, C, D (X) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | E (X) | water | water | 18.0 | 124 | Chemie (HOH) |
Sequence modifications
X: 1 - 313 (UniProt: P04818)
| PDB | External Database | Details |
|---|---|---|
| Phe 3 | Val 3 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35811.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 288.2 | |
| All* | Total formula weight | 36099.2 |
