3EAW
Replacement of Val3 in Human Thymidylate Synthase Affects Its Kinetic Properties and Intracellular Stability
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | X | Thymidylate synthase | polymer | 313 | 35979.2 | 1 | UniProt (P04818) Pfam (PF00303) In PDB | Homo sapiens (human) | TSase, TS |
| 2 | X | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 3 | X | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | water | water | 18.0 | 156 | Chemie (HOH) |
Sequence modifications
X: 1 - 313 (UniProt: P04818)
| PDB | External Database | Details |
|---|---|---|
| Tyr 3 | Val 3 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35979.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 446.3 | |
| All* | Total formula weight | 36425.5 |
