3E7O

Crystal Structure of JNK2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Mitogen-activated protein kinase 9	polymer	360	41271.4	2	UniProt (P45984) Pfam (PF00069) In PDB	Homo sapiens (human)	Stress-activated protein kinase JNK2, c-Jun N-terminal kinase 2, JNK-55
2	A, B	N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide	non-polymer		370.4	2	Chemie (35F)
3		water	water		18.0	251	Chemie (HOH)

Sequence modifications

A, B: 7 - 362 (UniProt: P45984)

PDB	External Database	Details
Gly 3	-	expression tag
Ser 4	-	expression tag
His 5	-	expression tag
Met 6	-	expression tag
Ser 177	Cys 177	engineered mutation
Ser 222	Cys 222	engineered mutation
Ala 250	Lys 250	engineered mutation
Ala 251	Lys 251	engineered mutation
Ala 265	Lys 265	engineered mutation
Ala 270	Lys 270	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	82542.9
Non-Polymers*	Number of molecules	2
	Total formula weight	740.7
All*	Total formula weight	83283.6

*Water molecules are not included.