3E7C
Glucocorticoid Receptor LBD bound to GSK866
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, B) | Glucocorticoid receptor | polymer | 257 | 29841.7 | 2 | UniProt (P04150) Pfam (PF00104) | Homo sapiens (Human) | GR, Nuclear receptor subfamily 3 group C member 1 |
| 2 | B, D (H, D) | Nuclear receptor coactivator 2 | polymer | 11 | 1349.6 | 2 | UniProt (Q15596) | Homo sapiens | NCoA-2, Transcriptional intermediary factor 2 |
| 3 | E, G (A, B) | 5-amino-N-[(2S)-2-({[(2,6-dichlorophenyl)carbonyl](ethyl)amino}methyl)-3,3,3-trifluoro-2-hydroxypropyl]-1-(4-fluorophenyl)-1H-pyrazole-4-carboxamide | non-polymer | 562.3 | 2 | Chemie (866) | |||
| 4 | F, H, I (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | J, K, L (A, H, B) | water | water | 18.0 | 93 | Chemie (HOH) |
Sequence modifications
A, B: 525 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Tyr 602 | Phe 602 | engineered mutation |
| Gly 638 | Cys 638 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62382.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1401.0 | |
| All* | Total formula weight | 63783.6 |
