3E3Q

Structure of the 3alpham13 high-affinity mutant of the 2C TCR in complex with Ld/QL9

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, CA, E, I, M... (A, B, c, H, L...)	H-2 class I histocompatibility antigen, L-D alpha chain	polymer	175	20541.6	8	UniProt (P01897) Pfam (PF00129)	Mus musculus (mouse)
2	B, DA, F, J, N... (Q, G, f, K, O...)	QL9 peptide	polymer	9	1063.2	8
3	AA, C, EA, G, K... (D, C, d, I, M...)	T-cell receptor alpha chain V region PHDS58	polymer	109	12071.6	8	UniProt (P01738) Pfam (PF07686) UniProt (by SIFTS) (Q5R1C2)	Mus musculus (mouse)
4	BA, D, FA, H, L... (E, F, e, J, N...)	TCR beta chain	polymer	111	12039.1	8		Mus musculus

Sequence modifications

A, B, c, H, L, P, U, Y: 1 - 175 (UniProt: P01897)

PDB	External Database	Details
Tyr 8	Phe 32	engineered mutation
Thr 12	Val 36	engineered mutation
Arg 15	Pro 39	engineered mutation
Thr 23	Ile 47	engineered mutation
Asp 30	Asn 54	engineered mutation
Val 49	Ala 73	engineered mutation
Val 66	Ile 90	engineered mutation
Arg 97	Trp 121	engineered mutation
Arg 131	Lys 155	engineered mutation

D, C, d, I, M, R, V, Z: 2 - 115 (UniProt: P01738)

PDB	External Database	Details
Pro 43	Leu 63	engineered mutation
Arg 82	Trp 102	engineered mutation
Asp 99	Gly 114	engineered mutation
Pro 100	Phe 115	engineered mutation
Pro 101	Ala 116	engineered mutation
Pro 102	Ser 117	engineered mutation
Leu 103	Ala 118	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	32
	Total formula weight	365724.4
All*	Total formula weight	365724.4

*Water molecules are not included.