3E2U

Crystal structure of the zink-knuckle 2 domain of human CLIP-170 in complex with CAP-Gly domain of human dynactin-1 (p150-GLUED)

Replaces:  2PZO

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Dynactin subunit 1	polymer	97	10309.4	4	UniProt (Q14203) Pfam (PF01302) In PDB	Homo sapiens (Human)	150 kDa dynein-associated polypeptide, DAP-150, DP-150, p150-glued, p135
2	E, F, G, H	CAP-Gly domain-containing linker protein 1	polymer	42	4804.1	4	UniProt (P30622) Pfam (PF16641) In PDB	Homo sapiens (Human)	Restin, Cytoplasmic linker protein 170 alpha-2, CLIP-170, Reed-Sternberg intermediate filament-associated protein, Cytoplasmic linker protein 1
3	E, F, G, H	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
4		water	water		18.0	58	Chemie (HOH)

Sequence modifications

A, B, C, D: 18 - 111 (UniProt: Q14203)

PDB	External Database	Details
Gly 15	-	expression tag
Ser 16	-	expression tag
His 17	-	expression tag

E, F, G, H: 1388 - 1427 (UniProt: P30622)

PDB	External Database	Details
Gly 1386	-	expression tag
Ser 1387	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	60454.1
Non-Polymers*	Number of molecules	4
	Total formula weight	261.6
All*	Total formula weight	60715.7

*Water molecules are not included.