3E1Y

Crystal structure of human eRF1/eRF3 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Eukaryotic peptide chain release factor subunit 1	polymer	451	50700.5	4	UniProt (P62495) Pfam (PF03463) Pfam (PF03464) Pfam (PF03465) In PDB	Homo sapiens (Human)	eRF1, Eukaryotic release factor 1, TB3-1, Protein Cl1
2	E, F, G, H	Eukaryotic peptide chain release factor GTP-binding subunit ERF3A	polymer	204	22579.5	4	UniProt (P15170) Pfam (PF03144) Pfam (PF22594) In PDB	Homo sapiens (Human)	Eukaryotic peptide chain release factor subunit 3a, eRF3a, G1 to S phase transition protein 1 homolog
3	A, B	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	2	Chemie (ATP)

Sequence modifications

A, B, C, D: 1 - 437 (UniProt: P62495)

PDB	External Database	Details
Met -13	-	expression tag
Arg -12	-	expression tag
Gly -11	-	expression tag
Ser -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Gly -3	-	expression tag
Met -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag

E, F, G, H: 439 - 637 (UniProt: P15170)

PDB	External Database	Details
Gly 434	-	expression tag
Pro 435	-	expression tag
Leu 436	-	expression tag
Gly 437	-	expression tag
Ser 438	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	293120.0
Non-Polymers*	Number of molecules	2
	Total formula weight	1014.4
All*	Total formula weight	294134.3

*Water molecules are not included.