Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3E1Y

Crystal structure of human eRF1/eRF3 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
A	0002184	biological_process	cytoplasmic translational termination
A	0003723	molecular_function	RNA binding
A	0003747	molecular_function	translation release factor activity
A	0004045	molecular_function	aminoacyl-tRNA hydrolase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006412	biological_process	translation
A	0006415	biological_process	translational termination
A	0006449	biological_process	regulation of translational termination
A	0006479	biological_process	protein methylation
A	0008079	molecular_function	translation termination factor activity
A	0016149	molecular_function	translation release factor activity, codon specific
A	0018444	cellular_component	translation release factor complex
A	0022626	cellular_component	cytosolic ribosome
A	0043022	molecular_function	ribosome binding
A	1990825	molecular_function	sequence-specific mRNA binding
B	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
B	0002184	biological_process	cytoplasmic translational termination
B	0003723	molecular_function	RNA binding
B	0003747	molecular_function	translation release factor activity
B	0004045	molecular_function	aminoacyl-tRNA hydrolase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006412	biological_process	translation
B	0006415	biological_process	translational termination
B	0006449	biological_process	regulation of translational termination
B	0006479	biological_process	protein methylation
B	0008079	molecular_function	translation termination factor activity
B	0016149	molecular_function	translation release factor activity, codon specific
B	0018444	cellular_component	translation release factor complex
B	0022626	cellular_component	cytosolic ribosome
B	0043022	molecular_function	ribosome binding
B	1990825	molecular_function	sequence-specific mRNA binding
C	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
C	0002184	biological_process	cytoplasmic translational termination
C	0003723	molecular_function	RNA binding
C	0003747	molecular_function	translation release factor activity
C	0004045	molecular_function	aminoacyl-tRNA hydrolase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006412	biological_process	translation
C	0006415	biological_process	translational termination
C	0006449	biological_process	regulation of translational termination
C	0006479	biological_process	protein methylation
C	0008079	molecular_function	translation termination factor activity
C	0016149	molecular_function	translation release factor activity, codon specific
C	0018444	cellular_component	translation release factor complex
C	0022626	cellular_component	cytosolic ribosome
C	0043022	molecular_function	ribosome binding
C	1990825	molecular_function	sequence-specific mRNA binding
D	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
D	0002184	biological_process	cytoplasmic translational termination
D	0003723	molecular_function	RNA binding
D	0003747	molecular_function	translation release factor activity
D	0004045	molecular_function	aminoacyl-tRNA hydrolase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006412	biological_process	translation
D	0006415	biological_process	translational termination
D	0006449	biological_process	regulation of translational termination
D	0006479	biological_process	protein methylation
D	0008079	molecular_function	translation termination factor activity
D	0016149	molecular_function	translation release factor activity, codon specific
D	0018444	cellular_component	translation release factor complex
D	0022626	cellular_component	cytosolic ribosome
D	0043022	molecular_function	ribosome binding
D	1990825	molecular_function	sequence-specific mRNA binding
E	0005525	molecular_function	GTP binding
F	0005525	molecular_function	GTP binding
G	0005525	molecular_function	GTP binding
H	0005525	molecular_function	GTP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ATP B 1526

Chain	Residue
A	THR58
A	ALA59
A	ILE62
B	LYS118
B	ASN121

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ATP A 1526

Chain	Residue
B	ILE62
A	LYS118
A	ASN121
B	THR58
B	ALA59

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0000269\|PubMed:12665801, ECO:0007744\|PubMed:19413330, ECO:0007744\|PubMed:22814378

Chain	Residue	Details
A	ALA2
B	ALA2
C	ALA2
D	ALA2

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: 4-hydroxylysine => ECO:0000269\|PubMed:24486019

Chain	Residue	Details
A	LYS63
B	LYS63
C	LYS63
D	LYS63

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N5-methylglutamine => ECO:0000269\|PubMed:18539146, ECO:0000269\|PubMed:20606008, ECO:0000269\|PubMed:26797129

Chain	Residue	Details
A	GLN185
B	GLN185
C	GLN185
D	GLN185

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	THR347
B	THR347
C	THR347
D	THR347

site_id	SWS_FT_FI5
Number of Residues	12
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
A	LYS87
D	LYS87
D	LYS404
A	LYS404
B	LYS87
B	LYS404
C	LYS87
C	LYS404

site_id	SWS_FT_FI6
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:37651229

Chain	Residue	Details
A	LYS279
B	LYS279
C	LYS279
D	LYS279

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)