3E0N

The X-ray structure of Human Prostasin in complex with DFFR-chloromethyl ketone inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B	Prostasin heavy chain	polymer	271	29608.0	1	UniProt (Q16651) Pfam (PF00089) In PDB	Homo sapiens (human)
2	A	DPN-PHE-ARM	polymer	3	466.6	1	BIRD (PRD_002526)	synthetic construct
3	B	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	B	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
5		water	water		18.0	245	Chemie (HOH)

Sequence modifications

B: 16 - 266 (UniProt: Q16651)

PDB	External Database	Details
Ser 122	Cys 154	conflict
Gln 127	Asn 159	conflict
Ser 170	Cys 203	conflict
His 263	Cys 306	conflict
His 264	Gly 307	conflict
His 265	Ser 308	conflict
His 267	-	expression tag
His 268	-	expression tag
His 269	-	expression tag
His 270	-	expression tag
His 271	-	expression tag
His 272	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	30074.6
Non-Polymers*	Number of molecules	5
	Total formula weight	468.4
All*	Total formula weight	30543.0

*Water molecules are not included.