3E0N
The X-ray structure of Human Prostasin in complex with DFFR-chloromethyl ketone inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Prostasin heavy chain | polymer | 271 | 29608.0 | 1 | UniProt (Q16651) Pfam (PF00089) | Homo sapiens (human) | |
| 2 | B (A) | DPN-PHE-ARM | polymer | 3 | 466.6 | 1 | BIRD (PRD_002526) | synthetic construct | |
| 3 | C, D (B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E, F, G (B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | H (B) | water | water | 18.0 | 245 | Chemie (HOH) |
Sequence modifications
B: 16 - 266 (UniProt: Q16651)
| PDB | External Database | Details |
|---|---|---|
| Ser 122 | Cys 154 | conflict |
| Gln 127 | Asn 159 | conflict |
| Ser 170 | Cys 203 | conflict |
| His 263 | Cys 306 | conflict |
| His 264 | Gly 307 | conflict |
| His 265 | Ser 308 | conflict |
| His 267 | - | expression tag |
| His 268 | - | expression tag |
| His 269 | - | expression tag |
| His 270 | - | expression tag |
| His 271 | - | expression tag |
| His 272 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 30074.6 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 468.4 | |
| All* | Total formula weight | 30543.0 |
