3E0N
The X-ray structure of Human Prostasin in complex with DFFR-chloromethyl ketone inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1 |
| Chain | Residue |
| B | HIS143 |
| B | HOH365 |
| B | HOH386 |
| B | HOH440 |
| B | ALA144 |
| B | PRO144 |
| B | SER144 |
| B | CYS191 |
| B | GLN192 |
| B | ALA218 |
| B | CYS219 |
| B | HOH283 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2 |
| Chain | Residue |
| B | SER20 |
| B | SER21 |
| B | ALA126 |
| B | SER236 |
| B | HOH316 |
| B | HOH330 |
| B | HOH441 |
| B | HOH463 |
| B | HOH473 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE DPN A 1 |
| Chain | Residue |
| B | GLU172 |
| B | PRO172 |
| B | TRP215 |
| B | GLY216 |
| B | ASP217 |
| A | PHE2 |
| A | ARM3 |
| B | HOH296 |
| B | HOH335 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PHE A 2 |
| Chain | Residue |
| B | HIS57 |
| B | GLY98 |
| B | SER99 |
| B | GLN192 |
| B | SER214 |
| B | TRP215 |
| A | DPN1 |
| A | ARM3 |
| B | HOH329 |
| site_id | AC5 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE ARM A 3 |
| Chain | Residue |
| B | HIS57 |
| B | ASP189 |
| B | ALA190 |
| B | CYS191 |
| B | GLN192 |
| B | GLY193 |
| B | SER195 |
| B | SER214 |
| B | TRP215 |
| B | GLY216 |
| B | ASP217 |
| B | GLY226 |
| A | DPN1 |
| A | PHE2 |
| B | HOH283 |
| B | HOH300 |
| B | HOH343 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 276 |
| Chain | Residue |
| B | GLU97 |
| B | PRO120 |
| B | SER122 |
| B | LEU206 |
| B | TRP207 |
| B | HOH309 |
| B | HOH464 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 277 |
| Chain | Residue |
| B | GLU58 |
| B | HIS58 |
| B | SER115 |
| B | ARG116 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 3 |
| Chain | Residue |
| B | GLN26 |
| B | TRP27 |
| B | TRP29 |
| B | HOH394 |
| B | HOH416 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| B | HIS57 | |
| B | ASP102 | |
| B | SER195 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| B | GLN127 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | HIS57 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | HIS57 | |
| B | GLY196 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | GLY193 | |
| B | HIS57 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | HIS57 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER195 | |
| B | GLY193 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER195 | |
| B | GLY196 |
