3DZI
Crystal structure of human CD38 extracellular domain, ribose-5'-phosphate intermediate/GTP complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | ADP-ribosyl cyclase 1 | polymer | 262 | 30380.4 | 2 | UniProt (P28907) Pfam (PF02267) | Homo sapiens | Cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, T10, CD38 antigen |
| 2 | C (A) | 2-amino-9-{5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-ribofuranosyl}-9H-purin-6-yl 5-O-phosphono-beta-D-ribofuranoside | non-polymer | 735.3 | 1 | Chemie (RGT) PubChem (49867602) | |||
| 3 | D (B) | ANY 5'-MONOPHOSPHATE NUCLEOTIDE | non-polymer | 214.1 | 1 | Chemie (N) | |||
| 4 | E (B) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 344 | Chemie (HOH) |
Sequence modifications
A, B: 45 - 300 (UniProt: P28907)
| PDB | External Database | Details |
|---|---|---|
| Lys 39 | - | expression tag |
| Arg 40 | - | expression tag |
| Glu 41 | - | expression tag |
| Ala 42 | - | expression tag |
| Glu 43 | - | expression tag |
| Ala 44 | - | expression tag |
| Thr 49 | Gln 49 | engineered mutation |
| Asp 100 | Asn 100 | engineered mutation |
| Asp 164 | Asn 164 | engineered mutation |
| Asp 209 | Asn 209 | engineered mutation |
| Asp 219 | Asn 219 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 60760.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1472.6 | |
| All* | Total formula weight | 62233.4 |
