3DXE

Crystal structure of the intracellular domain of human APP (T668A mutant) in complex with Fe65-PTB2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Amyloid beta A4 protein-binding family B member 1	polymer	140	15459.7	2	UniProt (O00213) Pfam (PF00640) In PDB	Homo sapiens (Human)
2	B, D	Amyloid beta A4 protein	polymer	35	4065.5	2	UniProt (P05067) Pfam (PF10515) In PDB	Homo sapiens (Human)
3		water	water		18.0	236	Chemie (HOH)

Sequence modifications

A, C: 534 - 667 (UniProt: O00213)

PDB	External Database	Details
His 668	-	expression tag
His 669	-	expression tag
His 670	-	expression tag
His 671	-	expression tag
His 672	-	expression tag
His 673	-	expression tag

B, D: 664 - 695 (UniProt: P05067)

PDB	External Database	Details
Gly 661	-	expression tag
Ala 662	-	expression tag
Met 663	-	expression tag
Ala 668	Thr 743	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	39050.3
All*	Total formula weight	39050.3

*Water molecules are not included.