3DVA
Snapshots of catalysis in the E1 subunit of the pyruvate dehydrogenase multi-enzyme complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, E, G | Pyruvate dehydrogenase E1 component subunit alpha | polymer | 369 | 41476.1 | 4 | UniProt (P21873) Pfam (PF00676) In PDB | Bacillus stearothermophilus | |
2 | B, D, F, H | Pyruvate dehydrogenase E1 component subunit beta | polymer | 325 | 35495.6 | 4 | UniProt (P21874) Pfam (PF02779) Pfam (PF02780) In PDB | Bacillus stearothermophilus | |
3 | I, J | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex | polymer | 428 | 46392.2 | 2 | UniProt (P11961) Pfam (PF00364) Pfam (PF02817) Pfam (PF00198) In PDB | Bacillus stearothermophilus | E2, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex |
4 | A, C, E, G | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
5 | A, C, E, G | 2-{4-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-3-METHYLTHIOPHEN-2-YL}ETHYL TRIHYDROGEN DIPHOSPHATE | non-polymer | 423.3 | 4 | Chemie (TPW) | |||
6 | B, D | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
7 | water | water | 18.0 | 1127 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 0 - 368 (UniProt: P21873)
PDB | External Database | Details |
---|---|---|
Ala 206 | Ile 207 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 10 |
Total formula weight | 400671.3 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 1917.3 | |
All* | Total formula weight | 402588.6 |