3DVA
Snapshots of catalysis in the E1 subunit of the pyruvate dehydrogenase multi-enzyme complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C, E, G (A, C, E, G) | Pyruvate dehydrogenase E1 component subunit alpha | polymer | 369 | 41476.1 | 4 | UniProt (P21873) Pfam (PF00676) | Bacillus stearothermophilus | |
| 2 | B, D, F, H (B, D, F, H) | Pyruvate dehydrogenase E1 component subunit beta | polymer | 325 | 35495.6 | 4 | UniProt (P21874) Pfam (PF02779) Pfam (PF02780) | Bacillus stearothermophilus | |
| 3 | I, J (I, J) | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex | polymer | 428 | 46392.2 | 2 | UniProt (P11961) Pfam (PF00364) Pfam (PF02817) Pfam (PF00198) | Bacillus stearothermophilus | E2, Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex |
| 4 | K, M, O, S, T... (A, C, E, G) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
| 5 | L, P, R, U (A, C, E, G) | 2-{4-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-3-METHYLTHIOPHEN-2-YL}ETHYL TRIHYDROGEN DIPHOSPHATE | non-polymer | 423.3 | 4 | Chemie (TPW) | |||
| 6 | N, Q (B, D) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 7 | AA, BA, CA, DA, EA... (E, F, G, H, I...) | water | water | 18.0 | 1127 | Chemie (HOH) |
Sequence modifications
A, C, E, G: 0 - 368 (UniProt: P21873)
| PDB | External Database | Details |
|---|---|---|
| Ala 206 | Ile 207 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 400671.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1917.3 | |
| All* | Total formula weight | 402588.6 |
