3DUH

Structure of Interleukin-23

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Interleukin-12 subunit beta	polymer	314	35811.1	2	UniProt (P29460) Pfam (PF10420)	Homo sapiens (human)	IL-12B, IL-12 subunit p40, Cytotoxic lymphocyte maturation factor 40 kDa subunit, CLMF p40, NK cell stimulatory factor chain 2, NKSF2
2	C, D (C, D)	Interleukin-23 subunit alpha	polymer	177	19638.2	2	UniProt (Q9NPF7) Pfam (PF16649)	Homo sapiens (human)	IL-23 subunit alpha, Interleukin-23 subunit p19, IL-23p19
3	E, F (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
4	G, H, I, J (A, B, C, D)	water	water		18.0	200	Chemie (HOH)

Sequence modifications

A, B: 1 - 306 (UniProt: P29460)

PDB	External Database	Details
Leu -1	-	expression tag
Glu 0	-	expression tag
His 307	-	expression tag
His 308	-	expression tag
His 309	-	expression tag
His 310	-	expression tag
His 311	-	expression tag
His 312	-	expression tag

C, D: 1 - 170 (UniProt: Q9NPF7)

PDB	External Database	Details
Leu 0	-	expression tag
His 171	-	expression tag
His 172	-	expression tag
His 173	-	expression tag
His 174	-	expression tag
His 175	-	expression tag
His 176	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	110898.5
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	111340.9

*Water molecules are not included.