3DTC
Crystal structure of mixed-lineage kinase MLK1 complexed with compound 16
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase kinase kinase 9 | polymer | 271 | 30252.1 | 1 | UniProt (P80192) Pfam (PF00069) | Homo sapiens (Human) | Mixed lineage kinase 1 |
| 2 | B (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | C (A) | 12-(2-hydroxyethyl)-2-(1-methylethoxy)-13,14-dihydronaphtho[2,1-a]pyrrolo[3,4-c]carbazol-5(12H)-one | non-polymer | 424.5 | 1 | Chemie (VIN) | |||
| 4 | D (A) | water | water | 18.0 | 43 | Chemie (HOH) |
Sequence modifications
A: 136 - 406 (UniProt: P80192)
| PDB | External Database | Details |
|---|---|---|
| Ala 312 | Thr 312 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30252.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 520.6 | |
| All* | Total formula weight | 30772.7 |
