3DTC

Crystal structure of mixed-lineage kinase MLK1 complexed with compound 16

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 8001

Chain	Residue
A	GLY154
A	PHE155
A	LYS270
A	SER372
A	THR373
A	HOH2006
A	HOH2021

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site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE VIN A 6331

Chain	Residue
A	PHE155
A	VAL158
A	ALA169
A	LYS171
A	MET220
A	GLU221
A	ALA223
A	ARG224
A	GLY226
A	ARG230
A	SER272
A	LEU275
A	THR293
A	ASP294
A	ILE150
A	GLY151

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	22
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGIGGFGKVYrAfwigde............VAVK

Chain	Residue	Details
A	ILE150-LYS171

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site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKssNILI

Chain	Residue	Details
A	ILE264-ILE276

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027

Chain	Residue	Details
A	ASP268

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE150

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	LYS171

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site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:15610029

Chain	Residue	Details
A	THR304
A	THR305
A	ALA312

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:15610029

Chain	Residue	Details
A	SER308

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