3DKG
Structure of Mutant(Y1248L) MET receptor tyrosine kinase in complex with inhibitor SGX-523
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Hepatocyte growth factor receptor | polymer | 317 | 35700.3 | 1 | UniProt (P08581) Pfam (PF07714) In PDB | Homo sapiens (human) | HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met |
| 2 | A | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 3 | A | 6-{[6-(1-methyl-1H-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]sulfanyl}quinoline | non-polymer | 359.4 | 1 | Chemie (SX8) | |||
| 4 | water | water | 18.0 | 167 | Chemie (HOH) |
Sequence modifications
A: 1049 - 1360 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Gly 1046 | - | expression tag |
| Ser 1047 | - | expression tag |
| Leu 1048 | - | expression tag |
| Phe 1194 | Tyr 1194 | engineered mutation |
| Leu 1230 | Tyr 1230 | engineered mutation |
| Phe 1234 | Tyr 1234 | engineered mutation |
| Asp 1235 | Tyr 1235 | engineered mutation |
| Glu 1361 | - | expression tag |
| Gly 1362 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35700.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 394.9 | |
| All* | Total formula weight | 36095.2 |
