3DKG

Structure of Mutant(Y1248L) MET receptor tyrosine kinase in complex with inhibitor SGX-523

Experimental procedure

Experimental method	SINGLE WAVELENGTH
Source type	SYNCHROTRON
Source details	APS BEAMLINE 31-ID
Synchrotron site	APS
Beamline	31-ID
Temperature [K]	100
Detector technology	CCD
Collection date	2007-07-18
Detector	MAR CCD 165 mm
Wavelength(s)	0.97969
Spacegroup name	P 21 21 21
Unit cell lengths	42.972, 46.452, 159.236
Unit cell angles	90.00, 90.00, 90.00

Refinement procedure

Resolution	27.100 - 1.910
Rwork	0.195
R-free	0.23800
Data scaling software	SCALA (3.2.5)
Refinement software	REFMAC

Data quality characteristics

	Overall
Low resolution limit [Å]	27.117
High resolution limit [Å]	1.909
Rmerge	0.154
Number of reflections	25227
<I/σ(I)>	4.1
Completeness [%]	98.3
Redundancy	6.6

Crystallization Conditions

crystal ID	method	pH	temperature	details
1	VAPOR DIFFUSION	5.8	292	11% ISOPROPANOL, 3% PEG 5K MME, 100 mM BIS-TRIS, pH 5.8, VAPOR DIFFUSION, temperature 292K