3DDC
Crystal Structure of NORE1A in Complex with RAS
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GTPase HRas | polymer | 166 | 18889.3 | 1 | UniProt (P01112) Pfam (PF00071) | Homo sapiens (human) | Transforming protein p21, p21ras, H-Ras-1, c-H-ras, Ha-Ras |
| 2 | B (B) | Ras association domain-containing family protein 5 | polymer | 163 | 18448.4 | 1 | UniProt (Q5EBH1) Pfam (PF00788) | Mus musculus (mouse) | New ras effector 1, Regulator for cell adhesion and polarization enriched in lymphoid tissues, RAPL, Effector protein NORE1A |
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | non-polymer | 522.2 | 1 | Chemie (GNP) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 115 | Chemie (HOH) |
Sequence modifications
A: 1 - 166 (UniProt: P01112)
B: 200 - 357 (UniProt: Q5EBH1)
| PDB | External Database | Details |
|---|---|---|
| Glu 30 | Asp 30 | engineered mutation |
| Lys 31 | Glu 31 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 195 | - | expression tag |
| Ser 196 | - | expression tag |
| Pro 197 | - | expression tag |
| Glu 198 | - | expression tag |
| Phe 199 | - | expression tag |
| Met 285 | Leu 285 | engineered mutation |
| Asp 302 | Lys 302 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 37337.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 546.5 | |
| All* | Total formula weight | 37884.1 |
