3D87

Crystal structure of Interleukin-23

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Interleukin-23 subunit p19	polymer	178	19669.1	2	UniProt (Q9NPF7) Pfam (PF16649)	Homo sapiens (human)	Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23p19
2	B, D (B, D)	Interleukin-12 subunit p40	polymer	306	34754.0	2	UniProt (P29460) Pfam (PF10420)	Homo sapiens (human)	IL-12B; IL-12 subunit p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; NK cell stimulatory factor chain 2; NKSF2
3	E, H (B, D)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
4	F, I (B, D)	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
5	G (D)	alpha-D-mannopyranose	non-polymer		180.2	1	Chemie (MAN)

Sequence modifications

A, C: 1 - 170 (UniProt: Q9NPF7)

PDB	External Database	Details
Gly 171	-	expression tag
Ser 172	-	expression tag
His 173	-	expression tag
His 174	-	expression tag
His 175	-	expression tag
His 176	-	expression tag
His 177	-	expression tag
His 178	-	expression tag

B, D: 1 - 306 (UniProt: P29460)

PDB	External Database	Details
Gln 200	Asn 222	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	108846.2
Non-Polymers*	Number of molecules	5
	Total formula weight	448.3
All*	Total formula weight	109294.5

*Water molecules are not included.