3D87
Crystal structure of Interleukin-23
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Interleukin-23 subunit p19 | polymer | 178 | 19669.1 | 2 | UniProt (Q9NPF7) Pfam (PF16649) In PDB | Homo sapiens (human) | Interleukin-23 subunit alpha; IL-23 subunit alpha; IL-23p19 |
2 | B, D | Interleukin-12 subunit p40 | polymer | 306 | 34754.0 | 2 | UniProt (P29460) Pfam (PF10420) In PDB | Homo sapiens (human) | IL-12B; IL-12 subunit p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; CLMF p40; NK cell stimulatory factor chain 2; NKSF2 |
3 | B, D | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
4 | B, D | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
5 | D | alpha-D-mannopyranose | non-polymer | 180.2 | 1 | Chemie (MAN) |
Sequence modifications
A, C: 1 - 170 (UniProt: Q9NPF7)
B, D: 1 - 306 (UniProt: P29460)
PDB | External Database | Details |
---|---|---|
Gly 171 | - | expression tag |
Ser 172 | - | expression tag |
His 173 | - | expression tag |
His 174 | - | expression tag |
His 175 | - | expression tag |
His 176 | - | expression tag |
His 177 | - | expression tag |
His 178 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gln 200 | Asn 222 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 108846.2 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 448.3 | |
All* | Total formula weight | 109294.5 |