3D42
Crystal structure of HePTP in complex with a monophosphorylated Erk2 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein phosphatase non-receptor type 7 | polymer | 308 | 35202.7 | 1 | UniProt (P35236) Pfam (PF00102) | Homo sapiens (human) | Protein-tyrosine phosphatase LC-PTP, Hematopoietic protein-tyrosine phosphatase, HEPTP |
| 2 | B (B) | Mitogen-activated protein kinase 1 peptide | polymer | 8 | 1033.0 | 1 | UniProt (P28482) | Extracellular signal-regulated kinase 2, ERK-2, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, p42-MAPK, ERT1 | |
| 3 | C (A) | D(-)-TARTARIC ACID | non-polymer | 150.1 | 1 | Chemie (TAR) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E (A) | water | water | 18.0 | 122 | Chemie (HOH) |
Sequence modifications
A: 44 - 339 (UniProt: P35236)
| PDB | External Database | Details |
|---|---|---|
| Met 32 | - | expression tag |
| Gly 33 | - | expression tag |
| Ser 34 | - | expression tag |
| Asp 35 | - | expression tag |
| Lys 36 | - | expression tag |
| Ile 37 | - | expression tag |
| His 38 | - | expression tag |
| His 39 | - | expression tag |
| His 40 | - | expression tag |
| His 41 | - | expression tag |
| His 42 | - | expression tag |
| His 43 | - | expression tag |
| Asp 106 | Thr 127 | engineered mutation |
| Ser 270 | Cys 291 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 36235.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 242.2 | |
| All* | Total formula weight | 36477.9 |
