3D42
Crystal structure of HePTP in complex with a monophosphorylated Erk2 peptide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Tyrosine-protein phosphatase non-receptor type 7 | polymer | 308 | 35202.7 | 1 | UniProt (P35236) Pfam (PF00102) In PDB | Homo sapiens (human) | Protein-tyrosine phosphatase LC-PTP, Hematopoietic protein-tyrosine phosphatase, HEPTP |
2 | B | Mitogen-activated protein kinase 1 peptide | polymer | 8 | 1033.0 | 1 | UniProt (P28482) In PDB | Extracellular signal-regulated kinase 2, ERK-2, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, p42-MAPK, ERT1 | |
3 | A | D(-)-TARTARIC ACID | non-polymer | 150.1 | 1 | Chemie (TAR) | |||
4 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
5 | water | water | 18.0 | 122 | Chemie (HOH) |
Sequence modifications
A: 44 - 339 (UniProt: P35236)
PDB | External Database | Details |
---|---|---|
Met 32 | - | expression tag |
Gly 33 | - | expression tag |
Ser 34 | - | expression tag |
Asp 35 | - | expression tag |
Lys 36 | - | expression tag |
Ile 37 | - | expression tag |
His 38 | - | expression tag |
His 39 | - | expression tag |
His 40 | - | expression tag |
His 41 | - | expression tag |
His 42 | - | expression tag |
His 43 | - | expression tag |
Asp 106 | Thr 127 | engineered mutation |
Ser 270 | Cys 291 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 36235.8 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 242.2 | |
All* | Total formula weight | 36477.9 |