3D42
Crystal structure of HePTP in complex with a monophosphorylated Erk2 peptide
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE TAR A 1 |
Chain | Residue |
A | HIS59 |
A | LEU328 |
A | PRO60 |
A | LEU61 |
A | THR62 |
A | ALA65 |
A | SER242 |
A | ALA243 |
A | GLY244 |
A | HIS324 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL A 2 |
Chain | Residue |
A | THR174 |
A | GLN175 |
A | ARG177 |
A | GLU181 |
A | LYS182 |
A | CYS183 |
A | ARG276 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine; by MAP2K1 and MAP2K2 => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
B | THR183 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: Phosphotyrosine; by MAP2K1 and MAP2K2 => ECO:0000269|PubMed:19053285, ECO:0000269|PubMed:19494114, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
B | PTR185 | |
A | SER270 | |
A | GLN314 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:19060905 |
Chain | Residue | Details |
B | THR188 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:10206983 |
Chain | Residue | Details |
A | SER72 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER89 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER122 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | MOD_RES: Cysteine sulfenic acid (-SOH) => ECO:0000250 |
Chain | Residue | Details |
A | SER270 |