3D2W

Crystal structure of mouse TDP-43 RRM2 domain in complex with DNA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	TAR DNA-binding protein 43	polymer	89	10097.5	1	UniProt (Q921F2) Pfam (PF00076)	Mus musculus (mouse)	TDP-43, RRM2 domain of mouse TDP-43
2	B (B)	DNA (5'-D(*DGP*DTP*DTP*DGP*DAP*DGP*DCP*DGP*DTP*DT)-3')	polymer	10	3091.0	1
3	C (B)	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
4	D, E (A, B)	water	water		18.0	116	Chemie (HOH)

Sequence modifications

A: 192 - 265 (UniProt: Q921F2)

PDB	External Database	Details
Met 180	-	expression tag
Arg 181	-	expression tag
Gly 182	-	expression tag
Ser 183	-	expression tag
His 184	-	expression tag
His 185	-	expression tag
His 186	-	expression tag
His 187	-	expression tag
His 188	-	expression tag
His 189	-	expression tag
Gly 190	-	expression tag
Ser 191	-	expression tag
Lys 266	-	expression tag
Leu 267	-	expression tag
Asn 268	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	13188.5
Non-Polymers*	Number of molecules	1
	Total formula weight	95.0
All*	Total formula weight	13283.5

*Water molecules are not included.