3D24

Crystal structure of ligand-binding domain of estrogen-related receptor alpha (ERRalpha) in complex with the peroxisome proliferators-activated receptor coactivator-1alpha box3 peptide (PGC-1alpha)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Steroid hormone receptor ERR1	polymer	253	27584.9	2	UniProt (P11474) Pfam (PF00104)	Homo sapiens	Estrogen-related receptor alpha, ERR-alpha, Estrogen receptor-like 1, Nuclear receptor subfamily 3 group B member 1
2	B, D (B, D)	Peroxisome proliferator-activated receptor gamma coactivator 1-alpha	polymer	22	2666.0	2	UniProt (Q9UBK2)		PPAR-gamma coactivator 1-alpha, PPARGC-1-alpha, PGC-1-alpha, Ligand effect modulator 6
3	E, F, G, H (A, B, C, D)	water	water		18.0	272	Chemie (HOH)

Sequence modifications

A, C: 192 - 423 (UniProt: P11474)

PDB	External Database	Details
Met 171	-	expression tag
Arg 172	-	expression tag
Ser 173	-	expression tag
His 174	-	expression tag
His 175	-	expression tag
His 176	-	expression tag
His 177	-	expression tag
His 178	-	expression tag
His 179	-	expression tag
Gly 180	-	expression tag
Pro 181	-	expression tag
Gly 182	-	expression tag
Leu 183	-	expression tag
Val 184	-	expression tag
Pro 185	-	expression tag
Arg 186	-	expression tag
Gly 187	-	expression tag
Ser 188	-	expression tag
Lys 189	-	expression tag
Thr 190	-	expression tag
Ala 191	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	60501.7
All*	Total formula weight	60501.7

*Water molecules are not included.