3CZU

Crystal structure of the human ephrin A2- ephrin A1 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Ephrin type-A receptor 2	polymer	207	23639.6	1	UniProt (P29317) Pfam (PF01404)	Homo sapiens	Tyrosine-protein kinase receptor ECK, Epithelial cell kinase
2	B (B)	Ephrin-A1	polymer	182	21469.8	1	UniProt (P20827) Pfam (PF00812)	Homo sapiens	EPH-related receptor tyrosine kinase ligand 1, LERK-1, Immediate early response protein B61, Tumor necrosis factor, alpha-induced protein 4
3	C (C)	alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G62182OO)
4	D, E (A, B)	water	water		18.0	72	Chemie (HOH)

Sequence modifications

A: 23 - 202 (UniProt: P29317)

PDB	External Database	Details
Ala -4	-	expression tag
Ala -3	-	expression tag
Pro -2	-	expression tag
Glu -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
Asp 6	-	expression tag
Tyr 7	-	expression tag
Asp 8	-	expression tag
Ile 9	-	expression tag
Pro 10	-	expression tag
Thr 11	-	expression tag
Thr 12	-	expression tag
Glu 13	-	expression tag
Asn 14	-	expression tag
Leu 15	-	expression tag
Tyr 16	-	expression tag
Phe 17	-	expression tag
Gln 18	-	expression tag
Gly 19	-	expression tag
Ala 20	-	expression tag
Met 21	-	expression tag
Asp 22	-	expression tag
Ile 94	Asn 94	SEE REMARK 999
Phe 95	Asn 95	SEE REMARK 999
Ile 96	Phe 96	SEE REMARK 999
Lys 99	Asn 99	SEE REMARK 999

B: 17 - 171 (UniProt: P20827)

PDB	External Database	Details
Ala -10	-	expression tag
Ala -9	-	expression tag
Pro -8	-	expression tag
Glu -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
Asp 0	-	expression tag
Tyr 1	-	expression tag
Asp 2	-	expression tag
Ile 3	-	expression tag
Pro 4	-	expression tag
Thr 5	-	expression tag
Thr 6	-	expression tag
Glu 7	-	expression tag
Asn 8	-	expression tag
Leu 9	-	expression tag
Tyr 10	-	expression tag
Phe 11	-	expression tag
Gln 12	-	expression tag
Gly 13	-	expression tag
Ala 14	-	expression tag
Met 15	-	expression tag
Asp 16	-	expression tag
Val 159	Asp 159	variant

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	45109.4
Branched	Number of molecules	1
	Total formula weight	586.5
All*	Total formula weight	45695.9

*Water molecules are not included.