3CWJ
Crystal structure of hcv ns5b polymerase with a novel pyridazinone inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | RNA-DIRECTED RNA POLYMERASE | polymer | 578 | 64345.7 | 2 | UniProt (Q99AU2) Pfam (PF00998) UniProt (by SIFTS) (P26663) | Hepatitis C virus | |
| 2 | C, D (A, B) | N-{3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-thiophen-2-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,4-benzothiazin-7-yl}methanesulfonamide | non-polymer | 536.6 | 2 | Chemie (321) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 570 (UniProt: Q99AU2)
| PDB | External Database | Details |
|---|---|---|
| Leu 571 | - | insertion |
| Glu 572 | - | insertion |
| His 573 | - | insertion |
| His 574 | - | insertion |
| His 575 | - | insertion |
| His 576 | - | insertion |
| His 577 | - | insertion |
| His 578 | - | insertion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 128691.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1073.3 | |
| All* | Total formula weight | 129764.8 |
