3CWJ

Crystal structure of hcv ns5b polymerase with a novel pyridazinone inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	RNA-DIRECTED RNA POLYMERASE	polymer	578	64345.7	2	UniProt (Q99AU2) Pfam (PF00998) UniProt (by SIFTS) (P26663) In PDB	Hepatitis C virus
2	A, B	N-{3-[5-hydroxy-2-(3-methylbutyl)-3-oxo-6-thiophen-2-yl-2,3-dihydropyridazin-4-yl]-1,1-dioxido-2H-1,4-benzothiazin-7-yl}methanesulfonamide	non-polymer		536.6	2	Chemie (321)
3		water	water		18.0	209	Chemie (HOH)

Sequence modifications

A, B: 1 - 570 (UniProt: Q99AU2)

PDB	External Database	Details
Leu 571	-	insertion
Glu 572	-	insertion
His 573	-	insertion
His 574	-	insertion
His 575	-	insertion
His 576	-	insertion
His 577	-	insertion
His 578	-	insertion

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	128691.5
Non-Polymers*	Number of molecules	2
	Total formula weight	1073.3
All*	Total formula weight	129764.8

*Water molecules are not included.