3CW1
Crystal Structure of Human Spliceosomal U1 snRNP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (V, v, w, x) | U1 snRNA | polymer | 138 | 44418.2 | 4 | Homo sapiens (human) | ||
| 2 | E, FA, N, W (D, S, T, U) | Small nuclear ribonucleoprotein Sm D3 | polymer | 126 | 13956.4 | 4 | UniProt (P62318) Pfam (PF01423) | Homo sapiens (human) | Sm-D3,snRNP core protein D3 |
| 3 | F, GA, O, X (A, H, I, J) | Small nuclear ribonucleoprotein-associated proteins B and B' | polymer | 174 | 18004.0 | 4 | UniProt (P14678) Pfam (PF01423) | Homo sapiens (human) | snRNP-B,Sm protein B/B',Sm-B/B',SmB/B' |
| 4 | G, HA, P, Y (B, M, N, O) | Small nuclear ribonucleoprotein Sm D1 | polymer | 119 | 13310.7 | 4 | UniProt (P62314) Pfam (PF01423) | Homo sapiens (human) | Sm-D1,Sm-D autoantigen,snRNP core protein D1 |
| 5 | H, IA, Q, Z (C, P, Q, R) | Small nuclear ribonucleoprotein Sm D2 | polymer | 118 | 13551.9 | 4 | UniProt (P62316) Pfam (PF01423) | Homo sapiens (human) | Sm-D2,snRNP core protein D2 |
| 6 | AA, I, JA, R (F, Z, 1, 2) | Small nuclear ribonucleoprotein F | polymer | 86 | 9734.2 | 4 | UniProt (P62306) Pfam (PF01423) | Homo sapiens (human) | snRNP-F,Sm protein F,Sm-F,SmF |
| 7 | BA, J, KA, S (E, W, X, Y) | Small nuclear ribonucleoprotein E | polymer | 92 | 10817.6 | 4 | UniProt (P62304) Pfam (PF01423) | Homo sapiens (human) | snRNP-E,Sm protein E,Sm-E,SmE |
| 8 | CA, K, LA, T (G, 3, 4, 5) | Small nuclear ribonucleoprotein G | polymer | 76 | 8508.1 | 4 | UniProt (P62308) Pfam (PF01423) | Homo sapiens (human) | snRNP-G,Sm protein G,Sm-G,SmG |
| 9 | DA, L, MA, U (K, 6, 7, 8) | U1 small nuclear ribonucleoprotein 70 kDa | polymer | 216 | 25372.8 | 4 | UniProt (P08621) Pfam (PF12220) Pfam (PF00076) | Homo sapiens (human) | U1 snRNP 70 kDa,U1-70K,snRNP70 |
| 10 | EA, M, NA, V (L, 9, 0, l) | U1 small nuclear ribonucleoprotein C | polymer | 77 | 8800.0 | 4 | UniProt (P09234) Pfam (PF06220) | Homo sapiens (human) | U1 snRNP C,U1-C,U1C |
| 11 | OA, PA, QA, RA (L, 9, 0, l) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) |
Sequence modifications
D, S, T, U: 1 - 126 (UniProt: P62318)
L, 9, 0, l: 1 - 77 (UniProt: P09234)
| PDB | External Database | Details |
|---|---|---|
| Cys 66 | Ser 66 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Cys 39 | Gln 39 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 40 |
| Total formula weight | 665895.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 261.6 | |
| All* | Total formula weight | 666157.0 |
