3CVM

High resolution structure of a stable Plasminogen activator inhibitor type-1 in its protease cleaved form

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Plasminogen activator inhibitor 1	polymer	392	44277.7	2	UniProt (P05121) Pfam (PF00079) In PDB	Homo sapiens (Human)	PAI-1, Endothelial plasminogen activator inhibitor, PAI
2		water	water		18.0	810	Chemie (HOH)

Sequence modifications

A, B: -2 - 379 (UniProt: P05121)

PDB	External Database	Details
Met -12	-	expression tag
Arg -11	-	expression tag
Gly -10	-	expression tag
Ser -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
Arg 10	His 33	variant
His 150	Asn 173	engineered mutation
Thr 154	Lys 177	engineered mutation
Leu 319	Gln 342	engineered mutation
Ile 354	Met 377	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	88555.3
All*	Total formula weight	88555.3

*Water molecules are not included.