3CRI

Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser, Glu82Asn and Lys101Ala

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Heparin-binding growth factor 1	polymer	146	16571.6	2	UniProt (P05230) Pfam (PF00167)	Homo sapiens (Human)	HBGF-1, Acidic fibroblast growth factor, aFGF, Beta-endothelial cell growth factor, ECGF-beta
2	C, E (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	D, F (A, B)	FORMIC ACID	non-polymer		46.0	2	Chemie (FMT)
4	G, H (A, B)	water	water		18.0	85	Chemie (HOH)

Sequence modifications

A, B: 1 - 140 (UniProt: P05230)

PDB	External Database	Details
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
Ser 81	Glu 96	engineered mutation
Asn 82	Glu 97	engineered mutation
Ala 101	Lys 116	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	33143.2
Non-Polymers*	Number of molecules	4
	Total formula weight	284.2
All*	Total formula weight	33427.4

*Water molecules are not included.