3CRH

Crystal structure of human fibroblast growth factor-1 with mutations Glu81Ser and Lys101Ala

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Heparin-binding growth factor 1	polymer	146	16586.6	2	UniProt (P05230) Pfam (PF00167)	Homo sapiens (Human)	HBGF-1, Acidic fibroblast growth factor, aFGF, Beta-endothelial cell growth factor, ECGF-beta
2	C, D, E, F, G (A, B)	SULFATE ION	non-polymer		96.1	5	Chemie (SO4)
3	H, I (A, B)	water	water		18.0	108	Chemie (HOH)

Sequence modifications

A, B: 1 - 140 (UniProt: P05230)

PDB	External Database	Details
His 0	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
His 1	-	expression tag
Ser 81	Glu 96	engineered mutation
Ala 101	Lys 116	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	33173.2
Non-Polymers*	Number of molecules	5
	Total formula weight	480.3
All*	Total formula weight	33653.5

*Water molecules are not included.