3CJ5
Crystal structure of hepatitis c virus rna-dependent rna polymerase ns5b in complex with optimized small molecule fragments
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | RNA-directed RNA polymerase | polymer | 576 | 64176.7 | 2 | UniProt (P26663) Pfam (PF00998) In PDB | Hepatitis C virus subtype 1b | NS5B, p68 |
2 | A, B | N-(4-bromo-2-{[(3R,5S)-3,5-dimethylpiperidin-1-yl]carbonyl}phenyl)-4-morpholin-4-yl-4-oxobutanamide | non-polymer | 480.4 | 2 | Chemie (SX6) | |||
3 | water | water | 18.0 | 633 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 570 (UniProt: P26663)
PDB | External Database | Details |
---|---|---|
Met -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
His 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 128353.3 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 960.8 | |
All* | Total formula weight | 129314.1 |