3C7I

X-RAY crystal structure of the complex between the grb2-sh2 domain and a flexible ligand, FPTVN.

Replaces:  2HUY

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Growth factor receptor-bound protein 2	polymer	116	13687.5	1	UniProt (P62993) Pfam (PF00017)	Homo sapiens (Human)	Adapter protein GRB2, SH2/SH3 adapter GRB2, Protein Ash
2	B (A)	N-{(2R)-4-(methylamino)-4-oxo-2-[4-(phosphonooxy)benzyl]butanoyl}-L-valyl-L-aspartamide	non-polymer		529.5	1	Chemie (TVN)
3	C (A)	FORMIC ACID	non-polymer		46.0	1	Chemie (FMT)
4	D (A)	water	water		18.0	121	Chemie (HOH)

Sequence modifications

A: 53 - 162 (UniProt: P62993)

PDB	External Database	Details
His 163	-	expression tag
His 164	-	expression tag
His 165	-	expression tag
His 166	-	expression tag
His 167	-	expression tag
His 168	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	13687.5
Non-Polymers*	Number of molecules	2
	Total formula weight	575.5
All*	Total formula weight	14263.0

*Water molecules are not included.