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3C6K

Crystal structure of human spermine synthase in complex with spermidine and 5-methylthioadenosine

Replaces:  2QFM
Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C, D
(A, B, C, D)
Spermine synthasepolymer38143002.94UniProt (P52788)
Pfam (PF17950)
Pfam (PF17284)
Pfam (PF01564)
Homo sapiens (human)Spermidine aminopropyltransferase, SPMSY
2E, G, I, K
(A, B, C, D)
SPERMIDINEnon-polymer145.24Chemie (SPD)
3F, H, J, L
(A, B, C, D)
5'-DEOXY-5'-METHYLTHIOADENOSINEnon-polymer297.34Chemie (MTA)
4M, N, O, P
(A, B, C, D)
waterwater18.01164Chemie (HOH)
Sequence modifications
A, B, C, D: 7 - 368 (UniProt: P52788)
PDBExternal DatabaseDetails
Met -12-expression tag
Gly -11-expression tag
Ser -10-expression tag
Ser -9-expression tag
His -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
His -3-expression tag
Ser -2-expression tag
Ser -1-expression tag
Gly 0-expression tag
Leu 1-expression tag
Val 2-expression tag
Pro 3-expression tag
Arg 4-expression tag
Gly 5-expression tag
Ser 6-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight172011.5
Non-Polymers*Number of molecules8
Total formula weight1770.3
All*Total formula weight173781.8
*Water molecules are not included.

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PDB entries from 2025-07-09

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