3C6K

Crystal structure of human spermine synthase in complex with spermidine and 5-methylthioadenosine

Replaces:  2QFM

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Spermine synthase	polymer	381	43002.9	4	UniProt (P52788) Pfam (PF17950) Pfam (PF17284) Pfam (PF01564)	Homo sapiens (human)	Spermidine aminopropyltransferase, SPMSY
2	E, G, I, K (A, B, C, D)	SPERMIDINE	non-polymer		145.2	4	Chemie (SPD)
3	F, H, J, L (A, B, C, D)	5'-DEOXY-5'-METHYLTHIOADENOSINE	non-polymer		297.3	4	Chemie (MTA)
4	M, N, O, P (A, B, C, D)	water	water		18.0	1164	Chemie (HOH)

Sequence modifications

A, B, C, D: 7 - 368 (UniProt: P52788)

PDB	External Database	Details
Met -12	-	expression tag
Gly -11	-	expression tag
Ser -10	-	expression tag
Ser -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
Ser -2	-	expression tag
Ser -1	-	expression tag
Gly 0	-	expression tag
Leu 1	-	expression tag
Val 2	-	expression tag
Pro 3	-	expression tag
Arg 4	-	expression tag
Gly 5	-	expression tag
Ser 6	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	172011.5
Non-Polymers*	Number of molecules	8
	Total formula weight	1770.3
All*	Total formula weight	173781.8

*Water molecules are not included.