3C6K
Crystal structure of human spermine synthase in complex with spermidine and 5-methylthioadenosine
Replaces: 2QFMFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0006555 | biological_process | methionine metabolic process |
| A | 0006595 | biological_process | polyamine metabolic process |
| A | 0006596 | biological_process | polyamine biosynthetic process |
| A | 0006597 | biological_process | spermine biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016768 | molecular_function | spermine synthase activity |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0005829 | cellular_component | cytosol |
| B | 0006555 | biological_process | methionine metabolic process |
| B | 0006595 | biological_process | polyamine metabolic process |
| B | 0006596 | biological_process | polyamine biosynthetic process |
| B | 0006597 | biological_process | spermine biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016768 | molecular_function | spermine synthase activity |
| B | 0070062 | cellular_component | extracellular exosome |
| C | 0005829 | cellular_component | cytosol |
| C | 0006555 | biological_process | methionine metabolic process |
| C | 0006595 | biological_process | polyamine metabolic process |
| C | 0006596 | biological_process | polyamine biosynthetic process |
| C | 0006597 | biological_process | spermine biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016768 | molecular_function | spermine synthase activity |
| C | 0070062 | cellular_component | extracellular exosome |
| D | 0005829 | cellular_component | cytosol |
| D | 0006555 | biological_process | methionine metabolic process |
| D | 0006595 | biological_process | polyamine metabolic process |
| D | 0006596 | biological_process | polyamine biosynthetic process |
| D | 0006597 | biological_process | spermine biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016768 | molecular_function | spermine synthase activity |
| D | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SPD A 501 |
| Chain | Residue |
| A | ASP169 |
| A | HOH537 |
| A | HOH574 |
| A | VAL170 |
| A | ASN171 |
| A | TYR179 |
| A | ASP278 |
| A | LEU279 |
| A | TYR353 |
| A | GLU355 |
| A | TRP357 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SPD B 501 |
| Chain | Residue |
| B | ASP169 |
| B | VAL170 |
| B | ASN171 |
| B | TYR179 |
| B | ASP278 |
| B | LEU279 |
| B | TYR353 |
| B | GLU355 |
| B | TRP357 |
| B | HOH522 |
| B | HOH530 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SPD C 501 |
| Chain | Residue |
| C | ASP169 |
| C | VAL170 |
| C | ASN171 |
| C | TYR179 |
| C | ASP278 |
| C | LEU279 |
| C | TYR353 |
| C | GLU355 |
| C | TRP357 |
| C | HOH752 |
| C | HOH778 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SPD D 501 |
| Chain | Residue |
| D | ASP169 |
| D | VAL170 |
| D | ASN171 |
| D | TYR179 |
| D | ASP278 |
| D | LEU279 |
| D | TYR353 |
| D | GLU355 |
| D | TRP357 |
| D | HOH687 |
| D | HOH689 |
| D | HOH692 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE MTA A 401 |
| Chain | Residue |
| A | GLN150 |
| A | LEU164 |
| A | LEU166 |
| A | ASN171 |
| A | GLY200 |
| A | GLY202 |
| A | ASP203 |
| A | VAL221 |
| A | GLU222 |
| A | ILE223 |
| A | ASP224 |
| A | VAL227 |
| A | ASP257 |
| A | CYS258 |
| A | ASP278 |
| A | LEU279 |
| A | THR280 |
| A | ILE284 |
| site_id | AC6 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE MTA B 401 |
| Chain | Residue |
| B | GLN150 |
| B | LEU164 |
| B | LEU166 |
| B | GLY200 |
| B | GLY201 |
| B | GLY202 |
| B | ASP203 |
| B | VAL221 |
| B | GLU222 |
| B | ILE223 |
| B | ASP224 |
| B | VAL227 |
| B | ASP257 |
| B | CYS258 |
| B | ASP278 |
| B | LEU279 |
| B | THR280 |
| B | ILE284 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE MTA C 401 |
| Chain | Residue |
| C | GLN150 |
| C | LEU164 |
| C | LEU166 |
| C | GLY200 |
| C | VAL221 |
| C | GLU222 |
| C | ILE223 |
| C | ASP224 |
| C | VAL227 |
| C | ASP257 |
| C | CYS258 |
| C | ASP278 |
| C | LEU279 |
| C | THR280 |
| C | ILE284 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE MTA D 401 |
| Chain | Residue |
| D | ASN171 |
| D | GLY200 |
| D | GLY202 |
| D | VAL221 |
| D | GLU222 |
| D | ILE223 |
| D | VAL227 |
| D | ASP257 |
| D | CYS258 |
| D | ASP278 |
| D | LEU279 |
| D | THR280 |
| D | ILE284 |
| D | GLN150 |
| D | LEU164 |
| D | LEU166 |
Functional Information from PROSITE/UniProt
| site_id | PS01330 |
| Number of Residues | 14 |
| Details | PABS_1 Polyamine biosynthesis (PABS) domain signature. VLILGGGdGgiLcE |
| Chain | Residue | Details |
| A | VAL196-GLU209 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00354","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18367445","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18367445","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
