3BUK

Crystal Structure of the Neurotrophin-3 and p75NTR Symmetrical Complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Neurotrophin-3	polymer	119	13649.4	2	UniProt (P20783) Pfam (PF00243)	Homo sapiens (human)	NT-3, Neurotrophic factor, HDNF, Nerve growth factor 2, NGF-2
2	C, D (C, D)	Tumor necrosis factor receptor superfamily member 16	polymer	167	18059.9	2	UniProt (P07174) Pfam (PF00020)	Rattus norvegicus (rat)	Low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR
3	E, F (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
4	G, H, I, J (A, B, C, D)	water	water		18.0	143	Chemie (HOH)

Sequence modifications

C, D: 1 - 161 (UniProt: P07174)

PDB	External Database	Details
Ser 42	Asn 70	engineered mutation
His 162	-	expression tag
His 163	-	expression tag
His 164	-	expression tag
His 165	-	expression tag
His 166	-	expression tag
His 167	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	63418.5
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	63861.0

*Water molecules are not included.