3BU0
crystal structure of human ABH2 cross-linked to dsDNA with cofactors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 | polymer | 203 | 23064.4 | 1 | UniProt (Q6NS38) Pfam (PF13532) | Homo sapiens (human) | Alkylated DNA repair protein alkB homolog 2, Oxy DC1 |
| 2 | B (B) | DNA (5'-D(*CP*TP*GP*TP*AP*TP*(2YR)P*AP*TP*TP*GP*CP*G)-3') | polymer | 13 | 4017.7 | 1 | |||
| 3 | C (C) | DNA (5'-D(*DTP*DCP*DGP*DCP*DAP*DAP*DTP*DAP*DAP*DTP*DAP*DCP*DA)-3') | polymer | 13 | 3943.6 | 1 | |||
| 4 | D (A) | 2-OXOGLUTARIC ACID | non-polymer | 146.1 | 1 | Chemie (AKG) | |||
| 5 | E (A) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 6 | F, G, H (A, B, C) | water | water | 18.0 | 91 | Chemie (HOH) |
Sequence modifications
A: 56 - 258 (UniProt: Q6NS38)
| PDB | External Database | Details |
|---|---|---|
| Ser 67 | Cys 67 | engineered mutation |
| Ser 165 | Cys 165 | engineered mutation |
| Cys 175 | Glu 175 | engineered mutation |
| Ser 192 | Cys 192 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 31025.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 201.0 | |
| All* | Total formula weight | 31226.7 |
