3BSC
Crystal Structure of HCV NS5B Polymerase with a Novel Pyridazinone Inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | RNA-directed RNA polymerase | polymer | 578 | 64345.7 | 2 | UniProt (P26663) Pfam (PF00998) In PDB | Hepatitis C virus (isolate BK) | NS5B, p68 |
2 | A, B | 5-hydroxy-4-(7-methoxy-1,1-dioxido-2H-1,2,4-benzothiadiazin-3-yl)-2-(3-methylbutyl)-6-phenylpyridazin-3(2H)-one | non-polymer | 468.5 | 2 | Chemie (2PD) | |||
3 | water | water | 18.0 | 243 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 570 (UniProt: P26663)
PDB | External Database | Details |
---|---|---|
Gln 544 | Arg 2963 | engineered mutation |
Leu 571 | - | expression tag |
Glu 572 | - | expression tag |
His 573 | - | expression tag |
His 574 | - | expression tag |
His 575 | - | expression tag |
His 576 | - | expression tag |
His 577 | - | expression tag |
His 578 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 128691.5 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 937.0 | |
All* | Total formula weight | 129628.5 |