3BRH
Protein Tyrosine Phosphatase PTPN-22 (Lyp) bound to the mono-Phosphorylated Lck active site peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Tyrosine-protein phosphatase non-receptor type 22 | polymer | 310 | 36395.7 | 2 | UniProt (Q9Y2R2) Pfam (PF00102) | Homo sapiens (Human) | Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP,Lymphoid phosphatase,LyP,PEST-domain phosphatase,PEP |
| 2 | C, D (C, D) | Lck Active Site Peptide | polymer | 7 | 868.9 | 2 | UniProt (by SIFTS) (P06239) | ||
| 3 | E, F (A, B) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 294 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 310 (UniProt: Q9Y2R2)
| PDB | External Database | Details |
|---|---|---|
| Ala 195 | Asp 195 | engineered mutation |
| Ser 227 | Cys 227 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 74529.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 189.9 | |
| All* | Total formula weight | 74719.1 |
