3BPO
Crystal structure of the IL13-IL4R-IL13Ra ternary complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Interleukin 13 | polymer | 127 | 14136.4 | 1 | UniProt (Q4VB50) Pfam (PF03487) UniProt (by SIFTS) (P35225) | Homo sapiens (human) | |
| 2 | B (B) | Interleukin-4 receptor alpha chain | polymer | 205 | 23470.3 | 1 | UniProt (P24394) Pfam (PF09238) | Homo sapiens (human) | IL-4R-alpha, CD124 antigen, Soluble interleukin-4 receptor alpha chain |
| 3 | C (C) | Interleukin-13 receptor alpha-1 chain | polymer | 314 | 36361.7 | 1 | UniProt (P78552) Pfam (PF18001) Pfam (PF09240) | Homo sapiens (human) | IL-13R-alpha-1, IL-13RA-1, Cancer/testis antigen 19, CT19, CD213a1 antigen |
| 4 | D (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | E (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 6 | F, G, H (A, B, C) | water | water | 18.0 | 54 | Chemie (HOH) |
Sequence modifications
B: 2 - 202 (UniProt: P24394)
| PDB | External Database | Details |
|---|---|---|
| Ala -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Phe 1 | - | expression tag |
| Gln 28 | Asn 53 | engineered mutation |
| Gln 73 | Asn 98 | engineered mutation |
| Gln 109 | Asn 134 | engineered mutation |
| Gln 151 | Asn 176 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 73968.4 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 74614.1 |
