3BPO

Crystal structure of the IL13-IL4R-IL13Ra ternary complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005126	molecular_function	cytokine receptor binding
A	0005576	cellular_component	extracellular region
A	0006955	biological_process	immune response
B	0002532	biological_process	production of molecular mediator involved in inflammatory response
B	0004896	molecular_function	cytokine receptor activity
B	0016020	cellular_component	membrane
C	0004896	molecular_function	cytokine receptor activity
C	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00838
Number of Residues	28
Details	INTERLEUKIN_4_13 Interleukins -4 and -13 signature. LrELIeelvnITqnqkaplCngsmVwSI

Chain	Residue	Details
A	LEU10-ILE37

---

site_id	PS01355
Number of Residues	31
Details	HEMATOPO_REC_S_F1 Short hematopoietin receptor family 1 signature. LksgisyrarVRawaqcyntt...........WSeWSpstkW

Chain	Residue	Details
B	LEU166-TRP196

---

site_id	PS01356
Number of Residues	32
Details	HEMATOPO_REC_S_F2 Short hematopoietin receptor family 2 signature. MkCsWlpGrntspDtnYtLyywhrslekihq..C

Chain	Residue	Details
C	MET142-CYS173

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Motif: {"description":"WSXWS motif"}

Chain

Residue

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site_id	SWS_FT_FI3
Number of Residues	3
Details	Site: {"description":"Major IL4 binding determinant"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	5
Details	Site: {"description":"Minor IL4 binding determinant"}

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