3BK3

Crystal structure of the complex of BMP-2 and the first Von Willebrand domain type C of Crossveinless-2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Bone morphogenetic protein 2	polymer	114	12875.9	2	UniProt (P12643) Pfam (PF00019) In PDB	Homo sapiens (Human)	BMP-2, BMP-2A
2	C, D	Crossveinless 2	polymer	67	7192.3	2	UniProt (Q5D734) In PDB	Danio rerio (Zebrafish)
3		water	water		18.0	47	Chemie (HOH)

Sequence modifications

A, B: 1 - 114 (UniProt: P12643)

PDB	External Database	Details
Met 41	Phe 323	engineered mutation
Met 91	Tyr 373	engineered mutation

C, D: 1 - 66 (UniProt: Q5D734)

PDB	External Database	Details
Trp -1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	40136.4
All*	Total formula weight	40136.4

*Water molecules are not included.