3BK0

Crystal Structure of Human Orotidine 5'-monophosphate Decarboxylase Complexed with 5-CN-UMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Uridine 5'-monophosphate synthase	polymer	279	30472.2	2	UniProt (P11172) Pfam (PF00215)	Homo sapiens (Human)	UMP synthase, Orotidine 5'-phosphate decarboxylase, OMPdecase
2	C, D (A)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	E, H (A, B)	5-CYANO-URIDINE-5'-MONOPHOSPHATE	non-polymer		349.2	2	Chemie (CNU)
4	F, G (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5	I, J (A, B)	water	water		18.0	256	Chemie (HOH)

Sequence modifications

A, B: 34 - 291 (UniProt: P11172)

PDB	External Database	Details
Met 13	-	expression tag
Gly 14	-	expression tag
Ser 15	-	expression tag
Ser 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
His 19	-	expression tag
His 20	-	expression tag
His 21	-	expression tag
His 22	-	expression tag
Ser 23	-	expression tag
Ser 24	-	expression tag
Gly 25	-	expression tag
Leu 26	-	expression tag
Val 27	-	expression tag
Pro 28	-	expression tag
Arg 29	-	expression tag
Gly 30	-	expression tag
Ser 31	-	expression tag
His 32	-	expression tag
Met 33	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	60944.3
Non-Polymers*	Number of molecules	6
	Total formula weight	1074.7
All*	Total formula weight	62019.0

*Water molecules are not included.