3BJU

Crystal Structure of tetrameric form of human lysyl-tRNA synthetase

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Lysyl-tRNA synthetase	polymer	521	60311.3	4	UniProt (Q15046) Pfam (PF01336) Pfam (PF00152)	Homo sapiens (human)	Lysine--tRNA ligase, LysRS
2	E, F, G, J, K... (A, B, C, D)	CALCIUM ION	non-polymer		40.1	12	Chemie (CA)
3	H, M, R, W (A, B, C, D)	LYSINE	non-polymer		147.2	4	Chemie (LYS)
4	I, N, S, X (A, B, C, D)	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	4	Chemie (ATP)
5	AA, BA, Y, Z (C, D, A, B)	water	water		18.0	1002	Chemie (HOH)

Sequence modifications

A, B, C, D: 70 - 582 (UniProt: Q15046)

PDB	External Database	Details
Met 69	-	expression tag
Leu 582	Val 582	engineered mutation
Glu 583	-	expression tag
His 584	-	expression tag
His 585	-	expression tag
His 586	-	expression tag
His 587	-	expression tag
His 588	-	expression tag
His 589	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	241245.2
Non-Polymers*	Number of molecules	20
	Total formula weight	3098.4
All*	Total formula weight	244343.6

*Water molecules are not included.